Course Description

This course provides an in-depth study of the physiology and regulation of hemostasis, and the genetic, molecular and cellular mechanisms underlying the pathophysiology of selected disorders of hemostasis. Utilization of appropriate laboratory tests for screening, diagnosis, and monitoring therapy will be discussed and applied through clinical scenarios and case studies. Review of current scientific literature and advanced laboratory practice issues will also be covered.

Credits/Modes of Instruction

Credits:  3

Web Based. Participants should anticipate spending approximately 135 hours on the course, or an average of 9-10 hours per week for 14 weeks. The course is web-based. Modes of instruction and course format include online instruction, online discussion and assignments, textbook, journal and internet readings, case studies, and directed study.

Prerequisites

Bachelor’s degree with previous course work and/or experience in hematology or hemostasis.

Course Goals and Outcomes:

Goals

After completion of the course, the student will have a thorough understanding of 1) the physiology and regulation of hemostasis; 2) the genetic, molecular, and cellular mechanisms underlying the pathophysiology of selected disorders of hemostasis; 3) the correlation of clinical and laboratory data in these conditions; and 4) the appropriate utilization of laboratory tests for screening, diagnosis, and monitoring therapy.

Upon completion of the course, the student will be able to:
Describe the physiology and regulation of the platelet, coagulation, coagulation inhibitor, and fibrinolytic systems in hemostasis.
Discuss the etiology and the genetic, molecular, and cellular mechanisms underlying the pathophysiology of selected hemorrhagic disorders of primary and secondary hemostasis and thrombotic conditions.
Discuss risk factors and appropriate laboratory testing in thrombophilia.
Describe and interpret clinical laboratory tests used in hemostasis testing.
Correlate laboratory data with patient history, symptoms, and clinical assessment data.
Recommend appropriate laboratory testing based on recognition of abnormal peripheral blood morphologic findings or abnormal laboratory screening results.
Compare and contrast the sensitivity and specificity of laboratory tests in the detection or monitoring of selected abnormalities.
Given a patient case scenario with laboratory data, evaluate the laboratory data to determine the possible disorders, the appropriateness of tests ordered, and the appropriate additional laboratory testing to confirm a diagnosis.
Discuss therapeutic options in selected hemostasis disorders and the laboratory tests needed to determine efficacy and ensure patient safety.
Interpret and analyze data from the scientific literature.